Journal
VACCINE
Volume 22, Issue 1, Pages 49-56Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00543-7
Keywords
DNA vaccine; tuberculosis; hsp65
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A DNA vaccine codifying the mycobacterial hsp65 can prevent infection with Mycobacterium tuberculosis in a prophylactic setting and also therapeutically reduce the number of bacteria in infected mice. The protective mechanism is thought to be related to Th1-mediated events that result in bacterial killing. To determine the best method of hsp65 introduction for vaccination efficacy against tuberculosis (TB), we evaluated the immunogenicity and protection of DNA-hsp65 administered by gene gun bombardment or intramuscular (i.m.) injection of naked DNA. Immunization by gene gun induced immune response with plasmid doses 100-fold lower than those required for intramuscular immunization. However, in contrast to intramuscular immunization, which was protective in these studies, gene gun immunization did not protect BALB/c mice against challenge infection. (C) 2003 Elsevier Ltd. All rights reserved.
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