Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 100, Issue 25, Pages 14864-14868Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2536658100
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Funding
- NICHD NIH HHS [HD36022, U54 HD012629, R01 HD036022, U54-HD12629] Funding Source: Medline
- NIDCR NIH HHS [DE13531] Funding Source: Medline
- NIGMS NIH HHS [T32-GM07270, T32 GM007270] Funding Source: Medline
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CatSper family proteins are putative ion channels expressed exclusively in membranes of the sperm flagellum and required for male fertility. Here, we show that mouse CatSper1 is essential for depolarization-evoked Ca2+ entry and for hyperactivated movement, a key flagellar function. CatSper1 is not needed for other developmental landmarks, including regional distributions of Ca(V)1.2, Ca(V)2.2, and Ca(V)2.3 ion channel proteins, the cAMP-mediated activation of motility by HCO3-, and the protein phosphorylation cascade of sperm capacitation. We propose that CatSper1 functions as a voltage-gated Ca2+ channel that controls Ca2+ entry to mediate the hyperactivated motility needed late in the preparation of sperm for fertilization.
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