Journal
BIOINFORMATICS
Volume 19, Issue 18, Pages 2461-2464Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btg357
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Motivation: Statistical methods usually used to perform Serial Analysis of Gene Expression (SAGE) analysis are based on hypothesis testing. They answer the biologist's question: 'what are the genes with differential expression greater than r with P-value smaller than P?'. Another useful and not yet explored question is: 'what is the uncertainty in differential expression ratio of a gene?'. Results: We have used Bayesian model for SAGE differential gene expression ratios as a more informative alternative to hypothesis tests since it provides credibility intervals.
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