Journal
VACCINE
Volume 22, Issue 2, Pages 257-267Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2003.07.008
Keywords
Hepatitis E virus; phage display; neutralization site
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In order to obtain monoclonal antibodies that might have prophylactic applications and to understand better the immune response to hepatitis E virus (HEV), we used phage display to isolate chimpanzee antibodies to HEV. The panning antigen was an two open reading frame (ORF2) recombinant protein that elicits a broadly protective immune response in vaccinated monkeys. Two major antigenic sites were identified on the ORF2 protein: one site was not accessible on the surface of infectious virions but the other site was accessible to antibodies and was recognized specifically by antibodies that neutralize the virus. Published by Elsevier Ltd.
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