Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 25, Pages 9861-9864Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo035356i
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A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of beta-amino acids.
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