Journal
MACROMOLECULAR BIOSCIENCE
Volume 3, Issue 12, Pages 758-764Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200300038
Keywords
enzyme inhibition; enzymatic polymerization; laccase; poly(catechin); superoxide radical scavenging
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Catechin was oxidatively polymerized by laccase in a mixture of a polar organic solvent and buffer to give a new class of flavonoid polymers. Myceliophthora laccase showed high catalytic activity for the polymerization. Using a mixed solvent of acetone and pH 5 acetate buffer efficiently produced the polymer. Under the selected conditions, DMF-soluble polymers were obtained in good yields. Effects of reaction parameters on the yield, solubility, and molecular weight of the polymer have been systematically investigated. A radical species was detected in the polymer by ESR spectroscopy. The polymers showed greatly amplified superoxide scavenging activity and xanthine oxidase inhibitory activity compared with monomeric catechin.
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