Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 25, Pages 9835-9838Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jo035256c
Keywords
-
Categories
Ask authors/readers for more resources
The synthesis of three constrained macrocyclic peptide analogues 1 of TMC-95A as potential proteasome inhibitors is described. The key step involves a Ni(0)-mediated macrocyclization of tripeptides 2 bearing halogenated aromatic side chains for the formation of the biaryl junction. In addition, an enantioselective preparation of L-7-bromotryptophan methyl ester 3 using a Corey-O'Donnell alkylation of the glycine benzophenone imine was achieved in good overall yield with very high ee (>85%) on a multigram scale.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available