Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 688, Issue 1-2, Pages 144-152Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2003.07.026
Keywords
antimalarial activity; heterobimetallic complexes; chloroquine
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The reaction of chloroquine and several ferrocenyl derivatives of chloroquine with Au(PPh3)NO3, Au(C6F5)(tht) and [Rh(COD)Cl](2) have been investigated. The resulting products have been characterised by a range of techniques including NMR, mass spectrometry, elemental analysis, IR and cyclic voltammetry. The data suggests that the products are heterobimetallic complexes where the quinoline nitrogen coordinates to the Au or Rh. In vitro studies against Plasmodium falciparum are reported. (C) 2003 Elsevier B.V. All rights reserved.
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