Journal
JOURNAL OF IMMUNOLOGY
Volume 171, Issue 12, Pages 6936-6940Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.171.12.6936
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Funding
- NIAID NIH HHS [AI50839] Funding Source: Medline
- NINDS NIH HHS [NS45443] Funding Source: Medline
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Estrogens are known to influence a variety of autoimmune diseases, but it is not known whether their actions are mediated through classic estrogen receptor alpha (ERalpha). The presence of a functional ER was demonstrated in secondary lymphoid tissues, then ERalpha expression was shown at both the RNA and protein levels in these tissues. Use of ERalpha knockout mice revealed that both the estrogen-induced disease protection and the estrogen-induced reduction in proinflammatory cytokines were dependent upon ERalpha in the prototypic Th1-mediated autoimmune disease experimental autoimmune encephalomyelitis. These findings are central to the design of selective ER modifiers which aim to target biologic responses in specific organ systems.
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