Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 13, Issue 24, Pages 4421-4425Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.09.027
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Funding
- NIDA NIH HHS [T32 DA07027] Funding Source: Medline
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A series of ring-substituted (i.e., methoxy and bromo) 3,4-dihydro- and 1,2,3,4-tetrahydro-beta-carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy- substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected beta-carbolines. (C) 2003 Elsevier Ltd. All rights reserved.
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