Journal
CLINICAL INFECTIOUS DISEASES
Volume 37, Issue 12, Pages E174-E176Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/379829
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Tenofovir- related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor ( PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal organic anion transporters, leading to nephrotoxic tubular concentrations of tenofovir and systemic accumulation of didanosine. Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine.
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