Journal
BLOOD
Volume 102, Issue 13, Pages 4407-4409Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-05-1602
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A20 binding inhibitor of NF-kappaB activetion-2, ABIN-2, is a newly identified intracellular protein that interacts with the zinc finger protein A20. ABIN-2 inhibits nuclear factor-kappaB (NF-kappaB) activity and is a possible effector of A20 regulation of NF-kappaB. Although A20 is a potent inhibitor of endothelial apoptosis, the effect of ABIN-2 on apoptosis is not known. ABIN-2 also interacts with the endothelial receptor Tie2. This receptor is essential for blood vessel formation and promotes endothelial survival. Here we examine the effects of ABIN-2 on endothelial cell apoptosis and its potential involvement in Tie2-mediated endothelial survival. ABIN-2 was found to inhibit endothelial apoptosis and rescue cells from death following growth factor deprivation. The inhibitors of phosphatidylinositol-3 kinase, wortmannin and LY294002, suppressed ABIN-2 inhibition of endothelial cell death. Deletion of the carboxy-terminus of ABIN-2 removed Its ability to inhibit apoptosis. Expression of truncated ABIN-2 prevented the Tie2-activating ligand anglopoletin-1 from inhibiting endothelial cell death. (C) 2003 by The American Society of Hematology.
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