Journal
NATURE
Volume 426, Issue 6968, Pages 891-894Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature02262
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Funding
- Telethon [GP0117Y01] Funding Source: Medline
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The endoplasmic reticulum (ER) is a factory where secretory proteins are manufactured, and where stringent quality-control systems ensure that only correctly folded proteins are sent to their final destinations. The changing needs of the ER factory are monitored by integrated signalling pathways that constantly adjust the levels of folding assistants. ER chaperones and signalling molecules are emerging as drug targets in amyloidoses and other protein-conformational diseases.
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