Journal
FEBS LETTERS
Volume 555, Issue 3, Pages 500-504Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01313-9
Keywords
aquaglyceroporin; water; glycerol; hydroxyurea; Toxoplasma; Plasmodium
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We describe a single aquaporin gene in Toxoplasma gondii which, surprisingly, has only 28% sequence similarity to the aquaglyceroporin of another apicomplexan parasite, Plasmodium falciparum. Sequence comparisons showed 47% similarity to water-specific plant aquaporins and the conservation of typical pore-forming residues. We established that the Toxoplasma aquaporin protein is a bifunctional membrane pore with intermediate water and high glycerol permeability. Furthermore, we identified hydroxyurea, an antineoplastic agent with inhibitory effects on parasite proliferation, as a permeant of this channel. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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