Journal
FEBS LETTERS
Volume 555, Issue 3, Pages 631-637Publisher
WILEY
DOI: 10.1016/S0014-5793(03)01343-7
Keywords
UCP3; thermogenesis; medium chain triacylglycerol; mitochondrion; high-fat diet; peroxisome proliferator-activated receptor; lipotoxicity
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We compared UCP3 protein in rat cardiac, glycolytic and oxidative skeletal muscle and examined the effect of high-fat medium chain vs. long chain triacylglycerol feeding on UCP3 content in these tissues. Cardiac muscle displays the lowest basal levels of UCP3 protein. Increasing long chain - but not medium chain - fatty acid supply upregulates UCP3 in all muscles. Since plasma non-esteritied fatty acids and the expression of two peroxisome proliferator-activated receptor (PPAR)responsive genes, were not different between groups, we conclude that the differential upregulation of UCP3 is not merely PPAR-mediated. This study supports a role of UCP3 in export of non-metabolizable fatty acids. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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