Journal
FEBS LETTERS
Volume 555, Issue 3, Pages 521-527Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)01336-X
Keywords
adenovirus; chromatin immunoprecipitation; histone chaperone; replication; transcription
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The adenovirus (Ad) genome complexed with viral core proteins designated Ad core is the template for transcription of early genes and the first round of replication in Ad-infected cells. A cellular protein designated template-activating factor-I (TAF-I) is found to be involved in remodeling of the Ad core in vitro. Here we found that TAF-I interacts with the Ad DNA through core protein VII in infected cells in early phases of infection. In vitro binding assays using recombinant proteins showed that TAF-I forms ternary complexes with DNA-protein VII complexes. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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