Journal
NEUROSCIENCE LETTERS
Volume 353, Issue 2, Pages 123-126Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.09.028
Keywords
childhood-onset growth hormone deficiency; growth hormone; insulin-like growth factor-1; selective attention; event-related potentials
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Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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