Journal
JOURNAL OF CELL BIOLOGY
Volume 163, Issue 6, Pages 1351-1362Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200306067
Keywords
cell contact; tetraspanin; phosphatase; tyrosine phosphorylation; PKC beta II
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Funding
- NEI NIH HHS [P30 EY011373, P0-EY11373, EY12251, R01 EY012251] Funding Source: Medline
- NIDDK NIH HHS [R01 DK057604, DK57604] Funding Source: Medline
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The beta1 family of integrins has been primarily studied as a set of receptors for the extracellular matrix. In this paper, we define a novel role for alpha3beta1 integrin in association with the tetraspanin CD151 as a component of a cell-cell adhesion complex in epithelial cells that directly stimulates cadherin-mediated adhesion. The integrin-tetraspanin complex affects epithelial cell-cell adhesion at the level of gene expression both by regulating expression of PTPmu and by organizing a multimolecular complex containing PKCbetaII, RACK1, PTPmu, beta-catenin, and E-cadherin. These findings demonstrate how integrin-based signaling can regulate complex biological responses at multiple levels to determine cell morphology and behavior.
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