Journal
MOLECULAR BRAIN RESEARCH
Volume 120, Issue 2, Pages 201-204Publisher
ELSEVIER
DOI: 10.1016/j.molbrainres.2003.10.018
Keywords
paraoxonase 2; apolipoprotein E; Alzheimer's disease; polymorphism
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The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese. (C) 2003 Elsevier B.V. All rights reserved.
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