4.4 Article

L-Proline promoted Ullmann-type coupling reactions of aryl iodides with indoles, pyrroles, imidazoles or pyrazoles

Journal

SYNLETT
Volume -, Issue 1, Pages 128-130

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-2003-44995

Keywords

cross coupling; nitrogen heterocycles; catalysis; aryl; iodide; additive

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The Ullmann-type coupling reactions of aryl iodides and several nitrogen heterocycles occur at 80-90 degreesC with L-proline as additive, giving N-arylpyrroles, N-arylindoles, N-arylimidazoles, and N-pyrazoles in good to excellent yields.

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