☆ 4.5 Article

Discovery of a novel bicycloproline P2 bearing peptidyl α-ketoamide LY514962 as HCV protease inhibitor

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

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Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 1, Pages 251-256

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2003.09.074

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Categories

Chemistry, Medicinal Chemistry, Organic

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We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles. (C) 2003 Elsevier Ltd. All rights reserved.

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