Journal
VIROLOGY
Volume 318, Issue 1, Pages 17-23Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2003.09.028
Keywords
HIV-1; DC-SIGN; dendritic cells; Raji cells; THP-1 cells; transmission
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Funding
- NCI NIH HHS [N01-CO-12400] Funding Source: Medline
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A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed THP-1 monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission. Published by Elsevier Inc.
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