Journal
FORENSIC SCIENCE INTERNATIONAL
Volume 139, Issue 1, Pages 57-60Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2003.09.011
Keywords
anaphylaxis; mast-cell tryptase; postmortem diagnosis
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An elevated serum tryptase concentration is considered to be a specific marker for systemic mast-cell activation, a central feature of anaphylaxis, which has been observed in some cases of sudden infant death syndrome (SIDS). However, it is still unclear whether anaphylaxis is involved in the etiology for SIDS. In the present study, we measured serum tryptase levels in 21 infants with SIDS, and 14 control infants from forensic autopsy cases by Uni-CAP TRYPTASE Fluoroenzyme immunoassay system, which detects both alpha- and beta-tryptase. The assay did not show any significant elevation of tryptase levels in the SIDS group compared with controls. Additionally, increased concentrations of tryptase were not observed in any SIDS case. Our results indicated that anaphylaxis does not seem to be involved in the etiology of SIDS. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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