Journal
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
Volume 95, Issue 6, Pages F435-F438Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/adc.2009.173575
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Funding
- EC
- BDF Newlife
- Mothercare Foundation
- NIHR Biomedical Research Centre in Cambridge
- Sallskapet Barnavard
- Stiftelsen Samariten
- Stiftelsen Frimurare Barnhuset
- Sven Jerring Foundation
- Cambridgeshire Ethics 2
- Karolinska ethics committee
- MRC [MC_U106179472] Funding Source: UKRI
- Medical Research Council [MC_U106179472] Funding Source: researchfish
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Objective To examine the role of androgens on birth weight in genetic models of altered androgen signalling. Setting Cambridge Disorders of Sex Development (DSD) database and the Swedish national screening programme for congenital adrenal hyperplasia (CAH). Patients (1) 29 girls with XY karyotype and mutation positive complete androgen insensitivity syndrome (CAIS); (2) 43 girls and 30 boys with genotype confirmed CAH. Main outcome measures Birth weight, birth weight-for-gestational-age (birth weight standard deviation score (SDS)) calculated by comparison with national references. Results Mean birth weight SDS in CAIS XY infants was higher than the reference for girls (mean, 95% CI: 0.4, 0.1 to 0.7; p=0.02) and was similar to the national reference for boys (0.1, -0.2 to 0.4). Birth weight SDS in CAN girls was similar to the national reference for girls (0.0, -0.2 to 0.2) and did not vary by severity of gene mutation. Birth weight SDS in CAH boys was also similar to the national reference for boys (0.2, -0.2 to 0.6). Conclusion CAIS XY infants have a birth weight distribution similar to normal male infants and birth weight is not increased in infants with CAN. Alterations in androgen signalling have little impact on birth weight. Sex dimorphism in birth size is unrelated to prenatal androgen exposure.
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