Journal
PHYSICS IN MEDICINE AND BIOLOGY
Volume 49, Issue 1, Pages 111-119Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/49/1/008
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Funding
- NCRR NIH HHS [RR-14069-02] Funding Source: Medline
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We describe a differential phase low-coherence interferometric probe for non-invasive, quantitative imaging of photothermal phenomena in biological materials. Our detection method utilizes principles of optical coherence tomography with differential phase measurement of interference fringe signals. A dual-channel optical low-coherence probe is used to analyse laser-induced thermoelastic and thermorefractive effects in tissue with micrometre axial resolution and nanometre sensitivity. We demonstrate an application of the technique using tissue phantoms and ex-vivo tissue specimens of rodent dorsal skin.
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