Journal
JOURNAL OF CONTROLLED RELEASE
Volume 94, Issue 1, Pages 187-193Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2003.10.008
Keywords
PEG-lipid conjugates; polymeric micelles; enhanced permeability and retention effect; infarct targeting; Gamma-imaging
Funding
- NIBIB NIH HHS [R01 EB001961] Funding Source: Medline
- NIGMS NIH HHS [R01 GM60200] Funding Source: Medline
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Micelles prepared from polyethyleneglycoUphosphatidyl-ethanotamine conjugates (PEG-PE) with a size of 7-20 nm and zeta-potential of approximately - 18 mV were administered i.v. to rabbits with experimental myocardial infarctions. Micelles demonstrated a prolonged circulation in the blood (half-life of 2 h) and accumulated in the infarction zone with efficiency more than 8-fold higher as compared to a non-damaged part of the heart muscle. Obtained results suggest that the enhanced permeability and retention (EPR) effect is the primary mechanism of accumulation of microparticles in the infarct areas, and that drug carriers such as PEG-PE micelles can be used for the delivery of therapeutic or diagnostic agents to an area of myocardial infarction. (C) 2003 Elsevier B.V. All rights reserved.
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