4.8 Article

Arylation of heterocycles via rhodium-catalyzed C-H bond functionalization

Journal

ORGANIC LETTERS
Volume 6, Issue 1, Pages 35-38

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol035985e

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Funding

  1. NIGMS NIH HHS [GM069559] Funding Source: Medline

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A new method for the rhodium-catalyzed arylation of a variety of heterocycles has been developed. The reaction provided moderate to good yields of the arylated products. A preliminary mechanistic investigation of this reaction revealed the intermediacy of an isolable N-heterocyclic carbene complex.

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