Journal
ORGANIC LETTERS
Volume 6, Issue 1, Pages 3-5Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol0354369
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(+/-)-Lysergic acid (1) has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
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