Journal
ORGANIC LETTERS
Volume 6, Issue 1, Pages 79-82Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol036113f
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A general method was developed for the one-pot synthesis of highly functionalized indoles from simple, commercially available aryl hydrazines and enol ethers. Enol lactones were also used as substrates, affording substituted indole acetic acid or indole propionic acid derivatives. This procedure affords 2,3-disubstituted indoles as single regioisomers from the appropriately substituted enol ether or enol lactone. This method was highlighted in the efficient synthesis of the antimigraine drug sumitriptan and the antiinflammatory drug indomethacin.
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