Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 483, Issue 2-3, Pages 223-227Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2003.10.029
Keywords
catechin; egpigallocatechin-3 gallate; VEGF (vascular endothelial growth factor); endothelial cell; cell proliferation
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Galloyl group-containing catechins, such as epigallocatechin-3 gallate, inhibit receptor tyrosine kinase activity of several growth factor receptors. This study investigated the effects of epigallocatechin-3 gallate, as compared to epicatechin, on vascular endothelial growth factor-induced intracellular signaling and mitogenesis of human umbilical endothelial cells. Epigallocatechin-3 gallate concentration-dependently inhibited vascular endothelial growth factor-induced DNA synthesis, cell proliferation, autophosphorylation of vascular endothelial growth factor receptors-1 and -2, phosphorylation of extracellular signal-regulated kinases-1 and -2, and mRNA expression of the early growth response factor-1. In contrast, epicatechin was not effective. Thus, epigallocatechin-3 gallate may be an attractive candidate drug to inhibit tumour angiogenesis. (C) 2003 Elsevier B.V. All rights reserved.
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