4.4 Article

Synthesis of calix[4]arene library substituted with peptides at the upper rim

Journal

TETRAHEDRON LETTERS
Volume 45, Issue 3, Pages 561-564

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2003.10.215

Keywords

calixarenes; combinatorial library; binding assay; chemosensors

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A fluorescence-labeled calix[4]arene library substituted with peptides at the upper rim was synthesized. Screening of the library for binding a dye-labeled oligopeptide indicated that some peptidocalix[4]arenes selectively bind the oligopeptide. The chemosensitivity of the library members for a target peptide was also investigated. (C) 2003 Elsevier Ltd. All rights reserved.

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