Journal
ONCOGENE
Volume 23, Issue 2, Pages 605-611Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207069
Keywords
PCGEM1; prostate-specific gene; prostate cancer; high-risk patients; cell proliferation
Funding
- NCI NIH HHS [1R01CA85596-01] Funding Source: Medline
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PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.
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