4.5 Article

The three-component reaction between isatin, α-amino acids, and dipolarophiles

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2004, Issue 2, Pages 413-418

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200300621

Keywords

alpha-amino acid; cycloadditions; nitrogen heterocycles

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3-Spiro[pyrrolidino-oxindoles] were prepared in high yields from a three-component reaction between isatin, an alpha-amino acid, and a dipolarophile. Both N-substituted and N-unsubstituted alpha-amino acids were used as the amine component. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004).

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