Journal
NEUROSCIENCE LETTERS
Volume 354, Issue 3, Pages 205-208Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.10.033
Keywords
cocaine self-administration; in vivo microdialysis; locomotor activity; extracellular dopamine; prelimbic prefrontal cortex; nucleus accumbens core
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Funding
- NIDA NIH HHS [R01 DA014640, DA014640] Funding Source: Medline
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Cocaine reinforcement is strongly associated with increased nucleus accumbens dopamine (NAcc DA). The involvement of medial prefrontal cortex (mPFC) DA in cocaine reward is less defined, but substantial evidence indicates that increased mPFC DA may suppress NAcc DA levels. Using in vivo microdialysis, NAcc or mPFC DA was determined in cocaine-naive rats after a self-administered cocaine injection (3.0 mg/kg). Extracellular levels of NAcc DA were dramatically enhanced 10 min post-cocaine injection, but dropped significantly at each subsequent assessment. mPFC DA also increased significantly, but to a lesser extent than observed in the NAcc. Findings of prominent DA increases in both the NAcc and mPFC terminals during the test session indicate that NAcc DA responses do not appear to be inhibited by increased mPFC DA during cocaine self-administration. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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