Journal
JOURNAL OF CELL BIOLOGY
Volume 164, Issue 2, Pages 169-174Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.200310027
Keywords
cell adhesion; Xenopus; cell movement; convergent extension; Wnt pathway
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Myristoylated alanine-rich C kinase substrate (MARCKS) is an actin-binding, membrane-associated protein expressed during Xenopus embryogenesis. We analyzed its function in cytoskeletal regulation during gastrulation. Here, we show that blockade of its function impaired morphogenetic movements, including convergent extension. MARCKS was required for control of cell morphology, motility, adhesion, protrusive activity, and cortical actin formation in embryonic cells. We also demonstrate that the noncanonical Wnt pathway promotes the formation of lamellipodia- and filopodia-like protrusions and that MARCKS is necessary for this activity. These findings show that MARCKS regulates the cortical actin formation that is requisite for dynamic morphogenetic movements.
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