Journal
NEUROREPORT
Volume 15, Issue 1, Pages 207-210Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200401190-00040
Keywords
alcohol withdrawal; anxiety; chronic intermittent ethanol; hyperexcitability; kindling; pentylentetrazol; topiramate
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Funding
- NIAAA NIH HHS [AA07680] Funding Source: Medline
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Topiramate, a novel anticonvulsant drug, has CNS depressant activity including enhancement of GABAergic inhibitory synaptic transmission. Drugs of this pharmacological spectrum might have utility in assuaging drug addiction. This study analyzes the ability of TPM to reduce withdrawal signs in the kindling model of ethanol dependence: chronic intermittent ethanol (CIE) rats. After CIE, persistent withdrawal signs are shown by an increased seizure susceptibility to the convulsant drug pentylenetetrazol and increased anxiety measured on the elevated plus-maze. Topiramate increased significantly the PTZ seizure threshold in CIE but not in control rats. On the elevated plus-maze, Topiramate was markedly more effective in CIE rats than in controls. Topiramate may have a therapeutic efficacy in treating alcohol withdrawal symptoms.
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