Lambertellols A and B, novel 3,4-dihydronaphthalen-1(2H)-ones with spiro-butenolide produced by Lambertella sp.1346

[GRAPHICS] Lambertella sp. 1346 was found to produce lambertellols A (1) and B (2) carrying a novel dihydronaphthalen-1(2H)-ones with spiro-1-furan-2(5'H)-one. The spiro-lactone ring moiety of both 1 and 2 were easily migrated to afford lambertellin, a known metabolite of Lambertella corni-maris. The absolute stereochemistry of these compounds was established on the basis of CD spectrum after chemical derivatization.