Journal
ORGANIC LETTERS
Volume 6, Issue 2, Pages 261-264Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol030135k
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[GRAPHICS] The multistep synthesis of a calixarene joined to a second calixarene via a long spacer is described. Since each calixarene bears multiple galactose-based units (known to bind strongly to rat hepatoma cells), there existed the possibility of cross-linking the cancer cells into a network. The compounds did not serve this purpose, a fact potentially correctable by adjusting or rigidifying the spacer. Formation of a,cancer net around a solid tumor remains a viable approach to retarding growth and/or inhibiting metastasis.
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