Journal
SCIENCE
Volume 303, Issue 5657, Pages 527-531Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1089353
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Funding
- NCI NIH HHS [CA58896] Funding Source: Medline
- NCRR NIH HHS [S10-RR10493, P41-RR10888, P20 RR16459] Funding Source: Medline
- NIAID NIH HHS [AI50216, AI30988] Funding Source: Medline
- NIAMS NIH HHS [AR48632] Funding Source: Medline
- NIGMS NIH HHS [GM62116, GM25845] Funding Source: Medline
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Unlike major histocompatibility proteins, which bind peptides, CD1 proteins display lipid antigens to T cells. Here, we report that CD1a presents a family of previously unknown lipopeptides from Mycobacterium tuberculosis, named didehydroxymycobactins because of their structural relation to mycobactin siderophores. T cell activation was mediated by the alphabeta T cell receptors and was specific for structure of the acyl and peptidic components of these antigens. These studies identify a means of intracellular pathogen detection and identify lipopeptides as a biochemical class of antigens for T cells, which, like conventional peptides, have a potential for marked structural diversity.
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