Journal
NEUROSCIENCE LETTERS
Volume 355, Issue 1-2, Pages 21-24Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.10.040
Keywords
depression; adenosine; forced swimming test; tail suspension test; CHA; DPMA; DPCPX; ZM241385
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This study investigated the effect of adenosine in the forced swimming test (FST) and the tail suspension test (TST) in mice, and the contribution of adenosine A(1) and A(2A) receptors to adenosine's antidepressant-like effect. The immobility time in the FST was reduced by adenosine given either by i.p. (5-10 mg/kg) or i.c.v. (0.01 - 10 mug/site) route. Adenosine (1 - 10 mg/kg, i.p.) also produced an antidepressant-like effect in the TST. No treatment affected locomotion in an open-field. The anti-immobility effect of adenosine (10 mg/kg, i.p.) in the FST was prevented by i.p. pretreatment of mice with caffeine (3 mg/kg), DPCPX (2 mg/kg) and ZM241385 (1 mg/kg). CHA (0.05 mg/kg, i.p.) and DPMA (1-5 mg/kg, i.p.) also produced an antidepressant-like effect in the FST. This is the first report of an antidepressant-like effect of adenosine in mice, apparently mediated through an interaction with A(1) and A(2A) receptors. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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