Journal
NEUROSCIENCE LETTERS
Volume 355, Issue 1-2, Pages 121-125Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2003.10.038
Keywords
intense tone exposure; spontaneous activity; dorsal cochlear nucleus; hamsters; tinnitus; hyperactivity
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Funding
- NIDCD NIH HHS [R01 DC03258] Funding Source: Medline
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Chronic increases in spontaneous multiunit activity c,m be induced in the dorsal cochlear nucleus (DCN) of hamsters by intense sound exposure (Kaltenbach and McCaslin, 1996). It has been hypothesized that this hyperactivity may represent a neural code that could underlie the sound percepts of tinnitus. The goal of the present study was to determine whether hyperactivity could be demonstrated in animals that had previously been tested for tinnitus, and, if so, whether animals differing in their behavioral evidence for tinnitus also differ in their levels of spontaneous activity. The results showed not only that levels of activity in exposed animals were higher than those in control animals, but the degree to which the activity was increased was related to the strength of the behavioral evidence for tinnitus. These findings are consistent with the hypothesis that hyperactivity in the DCN may be a physiological correlate of noise-induced tinnitus. (C) 2003 Published by Elsevier Ireland Ltd.
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