Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 34, Issue 1, Pages 233-238Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.japna.2003.08.005
Keywords
alginic acid; capillary electrophoresis; antacid formulations
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A capillary electrophoresis (CE) method has been developed and validated for the quantitative determination of alginic acid, which is used as a rafting agent in complex antacid formulations. The method involves a preliminary separation of the alginic acid from the formulation by washing the sample matrix with methanol, diluted HCl and water. This is followed by electrophoresis within a fused silica capillary using borate/boric acid buffer as the electrolyte, and the quantification is performed by a UV detector monitoring at 200 nm, where the intrinsic absorption of alginic acid is measured. An assay precision of better than 3% was achieved in intra- and interday determinations. No interference was found from the matrix of the antacid formulations. (C) 2003 Elsevier B.V. All rights reserved.
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