Journal
FEBS LETTERS
Volume 558, Issue 1-3, Pages 74-78Publisher
WILEY
DOI: 10.1016/S0014-5793(03)01530-8
Keywords
senescence; protein oxidation; methionine sulfoxide; protein repair; oxidative stress
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In contrast to other oxidative modifications of amino acids, methionine sulfoxide can be enzymatically reduced back to methionine in proteins by the peptide methionine sulfoxide reductase system, composed of MsrA and MsrB. The expression of MsrA and one member of the MsrB family, hCBS-1, was analyzed during replicative senescence of WI-38 human fibroblasts. Gene expression decreased for both enzymes in senescent cells compared to young cells, and this decline was associated with an alteration in catalytic activity and the accumulation of oxidized proteins during senescence. These results suggest that downregulation of MsrA and hCBS-1 can alter the ability of senescent cells to cope with oxidative stress, hence contributing to the age-related accumulation of oxidative damage. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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