Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 51, Issue 2, Pages 117-122Publisher
WILEY
DOI: 10.1046/j.8755-8920.2003.00128.x
Keywords
factor XIIIa; flow cytometry; laser scanning microscopy; M phi 2; placenta
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Problem: Depending on the type of their activation, macrophages may promote T(H)1- or T(H)2-type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which-together with NK cells-constitute the majority of bone marrow derived cells at this location. Method of Study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (Mphi2). Results: The markers MS-1 (stabilin-1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DMphi). In contrast, indoleamine 2,3-dioxygenase (IDO), an enzyme induced in macrophages by IFNgamma, was not present in DMphi. Conclusions: First trimester DMphi display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DMphi are not under a predominant influence of IFNgamma.
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