Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 113, Issue 3, Pages 340-345Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI200420986
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Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.
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