Journal
JOURNAL OF CELL SCIENCE
Volume 117, Issue 4, Pages 527-533Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.00973
Keywords
PCP; planar cell polarity; frizzled; dishevelled
Categories
Funding
- Telethon [TCP02006] Funding Source: Medline
Ask authors/readers for more resources
Planar cell polarity (PCP) has been demonstrated in the epithelium of organisms from flies to humans. Recent research has revealed that the planar organization of cells requires a conserved set of genes, known as the PCP genes. The PCP proteins Frizzled (Fz) and Dishevelled (Dsh) function as key players in PCP signalling. Although Fz and Dsh are also involved in Wingless (Wg)/Wnt signalling, these proteins have independent functions in a non-canonical pathway dedicated to PCP. Reorganization of the cell surface and cytoskeleton is required, and recent work has focused on how cell adhesion molecules (such as Fat, Dachsous and Flamingo) function in this process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available