Journal
MECHANISMS OF AGEING AND DEVELOPMENT
Volume 125, Issue 2, Pages 149-151Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/j.mad.2003.12.002
Keywords
Alzheimers; Alzheimer's vaccination; rhesus monkey; immunization
Categories
Ask authors/readers for more resources
Recent preliminary data suggest that vaccination with Alzheimer's Abeta might reduce senile plaque load and stabilize cognitive decline in human Alzheimer's disease. To examine the mechanisms and consequences of anti-Abeta-antibody formation in a species more closely related to humans, rhesus monkeys (Macaca mulatta) were vaccinated with aggregated Abeta(1-42). immunized monkeys developed anti-Abeta titers exceeding 1: 1000, and their plasma Abeta levels were 5-10-fold higher than the plasma Abeta levels observed in monkeys vaccinated with aggregated amylin. These data support the use of non-human primates to model certain phenomena associated with vaccination of humans with aggregated Alzheimer's Abeta. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available