Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 14, Issue 1, Pages 104-109Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2004.01.005
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Motions related to protein-protein binding events can be surveyed from the perspective of the Database of Macromolecular Movements. There are a number of alternative conceptual models that describe these events, particularly induced fit and pre-existing equilibrium. There is evidence for both alternatives from recent studies of conformational change. However, there is increasing support for the pre-existing equilibrium model, whereby proteins are found to simultaneously exist in populations of diverse conformations.
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