Journal
CELLULAR MICROBIOLOGY
Volume 6, Issue 2, Pages 97-104Publisher
WILEY
DOI: 10.1046/j.1462-5822.2003.00350.x
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Funding
- NEI NIH HHS [EY10320] Funding Source: Medline
- NIAID NIH HHS [K08 AI054652] Funding Source: Medline
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In this review, we describe the pathogenic role of Wolbachia endosymbiotic bacteria in filarial diseases, focusing on the host innate immune responses to filarial and Wolbachia products. A description of the host pathogen recognition and early inflammatory responses including TLR4-mediated signalling, chemokine and cytokine responses and inflammatory cell recruitment is provided from human studies and from animal models of filarial disease. Finally, the impact of the discovery and characterization of Wolbachia on filarial research and treatment programmes is discussed.
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