Journal
NATURAL PRODUCT REPORTS
Volume 21, Issue 1, Pages 122-142Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b302336m
Keywords
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Funding
- NCI NIH HHS [5R01CA79678-03, R01 CA079678] Funding Source: Medline
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This review discusses approaches to identify, clone, and express bioactive metabolite genes from symbionts of marine invertebrates. Criteria for proving symbiotic origin of bioactive metabolites are presented, followed by a comprehensive, practically-oriented overview of techniques to be applied. The Bugula neritina/Endobugula sertula association is used as a primary example, but other symbioses are discussed. Thirty-six compounds are presented and 111 references are cited.
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